I don't have any of your problems neither

For the slow mouse, you may try to change the driver from "OQO PS/2 Mouse" to "PS/2 Compatible Mouse". Just a guess: the OQO driver might connect it to other "enhancements" which, as always, usually mean poor performance. It may also fix your keyboard problem as the driver also control the keyboard port.
I've been using the general PS/2 mouse driver without any issue. I never run oqomanager.exe.
It is hard for me to trust system-level software that are not made by MS. System-level programming is not something most software engineers can do well. The worst system-level software I've seen so far are those from Symantec, anti-virus, anti-spyware, Internet security, undelete, backup, etc. If you want an efficient and reliable computer, remove all such system-level stuff.
I don't understand why oqo waste money and time to develop such "enhancements" that are not necessary and actually cause more troubles, especially while OQO models are struggling with Vista with relatively low performance CPU, inadequate memory and excessive heat. The only necessary function is brightness control; all other things are already handled very well by Windows. I'm grateful that the oqo engineers put some key keys such as keyboard backlight into BIOS. The engineers who customized Windows installation also did a fantastic job. OQO is so far the cleanest and best configured Windows out of box, among all the computers I have bought for all these years. They show file extensions, for example, and installed Firefox and AdBlock+, solute to you! My only suggestion is: don't install Acrobat and QT; instead, install the alternatives.